Characteristics | Univariable analyses | Model 1 Multivariable analyses | Model 2 Multivariable analyses | Model 3 Multivariable analyses | ||||
---|---|---|---|---|---|---|---|---|
HR (95%CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
Age (continuous) | 1.017 (1.008–1.027) | < 0.001* | 1.021 (1.012–1.031) | < 0.001* | 1.018 (1.008–1.027) | < 0.001* | 1.019 (1.009–1.028) | < 0.001* |
Sex (male vs. female) | 0.822 (0.617–1.096) | 0.182 | – | – | – | – | – | – |
Tumor location (left vs. right) | 0.981 (0.742–1.297) | 0.892 | – | – | – | – | – | – |
Tumor size (continuous) | 1.012 (0.993–1.032) | 0.227 | – | – | – | – | – | – |
7th AJCC T stage |  | < 0.001* |  | < 0.001* |  |  |  |  |
 T1 | Reference |  | Reference | – | – | – | – | – |
 T2 | 1.521 (0.734–3.154) | 0.260 | 1.544(0.743–3.208) | 0.244 | – | – | – | – |
 T3 | 3.412 (1.636–7.116) | 0.001* | 2.981 (1.428–6.225) | 0.004* | – | – | – | – |
 T4 | 4.364 (2.063–9.233) | < 0.001* | 3.105 (1.454–6.633) | 0.003* | – | – | – | – |
7th AJCC N stage (N0 vs. N1) | 3.448 (2.370–5.341) | < 0.001* | 2.789 (1.801–4.319) | < 0.001* | – | – | – | – |
7th AJCC M stage (M0 vs. M1) | 2.773 (2.019–3.808) | < 0.001* | 1.970 (1.391–2.791) | < 0.001* | – | – | – | – |
7th AJCC TNM stage |  | < 0.001* |  |  |  | < 0.001* |  |  |
 I | Reference |  | – | – | Reference |  | – | – |
 II | 1.297 (0.622–2.705) | 0.489 | – | – | 1.196 (0.572–2.498) | 0.634 | – | – |
 III | 2.599 (1.225–5.515) | 0.013* | – | – | 2.375 (1.117–5.049) | 0.025* | – | – |
 IV | 4.097 (1.976–8.498) | < 0.001* | – | – | 3.897 (1.878–8.087) | < 0.001* | – | – |
ENSAT stage group |  | < 0.001* |  |  |  |  |  |  |
 I | Reference |  | – | – | – | – | Reference | < 0.001* |
 II | 1.297 (0.622–2.706) | 0.488 | – | – | – | – | 1.191 (0.570–2.489) | 0.642 |
 III | 2.782 (1.339–5.779) | 0.006* | – | – | – | – | 2.545 (1.223–5.299) | 0.013* |
 IV | 4.891 (2.317–10.322) | < 0.001* | – | – | – | – | 4.752 (2.251–10.034) | < 0.001* |